Groundbreaking research uncovers how pancreatic cancer switches between two transcription factors for different stages of disease progression. The discovery reveals new therapeutic vulnerabilities in one of oncology’s most challenging cancers.
Groundbreaking research reveals how the protein PCNA acts as a master coordinator of DNA replication and repair processes. Scientists have identified multiple regulatory mechanisms that enable this crucial protein to prevent genomic instability and maintain cellular health.
Scientists have made significant progress in understanding how cells maintain genome integrity during the complex process of DNA replication, according to recent research published in Nature Reviews Molecular Cell Biology. At the heart of this process lies proliferating cell nuclear antigen (PCNA), a protein that serves as a central platform coordinating numerous factors involved in DNA replication and repair. Sources indicate that this molecular machinery is essential for preventing mutations that could lead to cancer and other diseases.
